Local and systemic actions of cardiac myostatin

What is the role of myostatin in the heart? Listen to our latest podcast on the Review article by Breitbart et al, as Editor in Chief William C. Stanley and Associate Editor Gary Lopaschuk interview lead author Joerg Heineke (University of Hannover, School of Medicine) to find out how and why myostatin puts the breaks on muscle growth.

Astrid Breitbart, Mannix Auger-Messier, Jeffery D Molkentin, and Joerg Heineke. Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting. Am J Physiol Heart Circ Physiol; published ahead of print March 18, 2011, doi:10.1152/ajpheart.00200.2011.

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Phospholemman, NA+/CA2+ exchanger, and cardiac contractility

In our latest podcast we present the article by Wang et al., which explores regulation of sodium-calcium exchange by phospholemman and the possible role of that in cardiac stress responses (such as fight-or-flight). Associate Editor W. Gil Wier moderates a discussion with renowned expert Donald M. Bers (University of California-Davis) and lead author Joseph Y. Cheung (Thomas Jefferson University), who examinethis innovative study and ponder the way to pin down the role of phospholemman at the molecular level.

JuFang Wang, Erhe Gao, Joseph Rabinowitz, Jianliang Song, Xue-Qian Zhang, Walter J. Koch, Amy L. Tucker, Tung O. Chan, Arthur M. Feldman, and Joseph Y.Cheung. Regulation of in vivo cardiac contractility by phospholemman:role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol 300: H859-H868, 2011.

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