Obesity and orthopedic trauma

The obesity epidemic in the United States shows no signs of abating, which is why our latest podcast is particularly insightful. Associate Editor Nancy Kanagy talks with author Lusha Xiang (University of Mississippi) and leading expert Jeff Frisbee (West Virginia University) about the study by Xiang and colleagues, which suggests the mechanism behind the poor prognosis for obese trauma victims and provides insight into a new therapeutic intervention to improve recovery of obese victims of traumatic injury.

Lusha Xiang, Silu Lu, William Fuller, Arun Aneja, George V Russell, Louis B Jones, and Robert L. Hester. Impaired blood pressure recovery to hemorrhage in obese Zucker rats with orthopedic trauma. Am J Physiol Heart Circ Physiol, published ahead of print October 14, 2011, doi: 10.1152/ajpheart.00439.2011.


Muscle oxygen transport and utilization in heart failure

A well-known problem for heart failure patients is the inability, or markedly decreased ability, to exercise. When even low levels of daily activity are impaired, the quality of life for heart failure patients suffers considerably. The mechanisms for exercise intolerance are very complicated and extend far beyond impaired cardiac performance. Listen in as Associate Editor Irving Zucker, senior author David Poole (Kansas State University) and leading expert Peter Wagner (University of California, San Diego) discuss the new Review article by Poole and colleagues, which tackles the mechanisms of muscle dysfunction in heart failure at the oxygen transport and microcirculatory levels.

David C. Poole, Daniel M. Hirai, Steven W. Copp, and Timothy I. Musch. Muscle Oxygen Transport and Utilization in Heart Failure: Implications for Exercise (In)tolerance Am J Physiol Heart Circ Physiol, published ahead of print November 18, 2011, doi:10.1152/ajpheart.00943.2011.


Interstitial Volume Modulates the Conduction Velocity- Gap Junction Relationship

What are the parameters which modulate conduction under normal and disease conditions in the heart? This age-old debate has pitted two distinct schools of thought against each other—ephaptic conduction vs. gap junctions. Can changes in interstitial volume by pharmacological means dramatically change conduction velocity? In our latest podcast on the article by Veeraraghavan et al, Associate Editor Igor Efimov, leading expert Craig Henriquez (Duke University) and senior author Steven Poelzing (University of Utah) wade into the debate.

Rengasayee Veeraraghavan, Mohamed E. Salama, and Steven Poelzing. Interstitial volume modulates the conduction velocity-gap junction relationship. Am J Physiol Heart Circ Physiol, published ahead of print October 21, 2011, doi: 10.1152/ajpheart.00868.2011.