Post-translational Modifications of Cardiac Proteasomes

What are the big questions surrounding our understanding of post-translational modifications (PTMs) of proteasomes? Associate Editor Meredith Bond interviews lead author Nobel Zong (UCLA) and expert Xuejun Wang (University of South Dakota) about the latest Review article by Scruggs et al from the lab of Peipei Ping and colleagues. Why are the reversible and permanent PTMs of proteasomes critical to our understanding of cardiac physiology? How will we correlate changes in PTMs of proteasomes with pathological and physiological changes in heart function? How will we deal with the increasingly large data sets generated? Listen now…

Sarah B. Scruggs, Nobel C. Zong, Ding Wang, Enrico Stefani, and Peipei Ping Post-translational Modification of Cardiac Proteasomes: Functional Delineation Enabled by Proteomics Am J Physiol Heart Circ Physiol, published online April 20, 2012, doi: 10.1152/ajpheart.00189.2012.

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Thromboxane A2-induced Vasoconstriction in Pregnant Rats

The vascular physiology of pregnancy still provide us with surprising observations. In our latest podcast, Associate Editor Nancy Kanagy interviews author Stella Goulopoulou (Georgia Health Sciences University) and leading expert George Osol (University of Vermont College of Medicine) about the new research published by Goulopoulou and colleagues. This work found that the contractile response to thromboxane in uterine arteries is mediated by a surprisingly unique signal transduction pathway. Will further exploration lead to new therapeutic targets for vascular abnormalities in pregnancy during conditions such as preeclampsia? Listen in and find out.

Styliani Goulopoulou, Johanna L. Hannan, Takayuki Matsumoto, and R. Clinton Webb Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in rat uterine artery Am J Physiol Heart Circ Physiol, published online April 27, 2012, doi:10.1152/ajpheart.00900.2011.

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Cerebrovascular Response After Long Duration Spaceflight

We tackle our most unique topic yet-- long duration spaceflight! In the micro-gravity environment of spaceflight, fluid shifts from the feet to the head. Over time this fluid shift increases pressure in the brain, a particular concern for long duration spaceflight astronauts. Listen as Consulting Editor John Longhurst interviews senior author Richard Hughson (University of Waterloo) and leading expert Ronney Panerai (University of Leicester) about alterations in cerebrovascular function pre- and post- long duration spaceflight, including anecdotes about the challenges of experiments involving astronauts in both the U.S.A. and Russia.

Kathryn A. Zuj, Philippe Arbeille, J. Kevin Shoemaker, Andrew P. Blaber, Danielle K. Greaves, Da Xu, and Richard L. Hughson Impaired cerebrovascular autoregulation and reduced CO2 reactivity after long duration spaceflight Am J Physiol Heart Circ Physiol, published online April 6, 2012, doi: 10.1152/ajpheart.00029.2012.

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