Researchers have long sought out early biomarkers of cardiac injury, and the new work by Kuster et al takes this search in an exciting new direction. Listen as Associate Editor Merry Lindsey (University of Mississippi Medical Center) interviews lead author Sakthivel Sadayappan (Loyola University Chicago) and expert Ying Ge (University of Wisconsin) about the recent discovery that cardiac muscle-specific myosin binding protein-C is an ultra-early biomarker of myocardial infarction. Will it be feasible to apply detection of myosin binging protein-C to a multi-marker regime, particularly in concert with cardiac troponins, in a clinical setting? Listen and learn.
Diederik Kuster, Adriana Cardenas-Ospina, Lawson Miller, Christoph Liebetrau, Christian Troidl, Holger M Nef, Helge Möllmann, Christian W Hamm, Karen S Pieper, Kenneth W Mahaffey, Neal S Kleiman, Bruno Daniel Stuyvers, A. J. Marian, Sakthivel Sadayappan Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury Am J Physiol Heart Circ Physiol, published December 13, 2013, DOI: 10.1152/ajpheart.00846.2013.