Optical Projection Tomography for Infarct Assessment

Is optical projection tomography (OPT) useful for producing more than just beautiful images? Yes, according to Zhao et al, who employed the innovative OPT methodology to quantify infarct size experimentally. In this podcast, Associate Editor Ajay Shah (King's College London) interviews lead author Gillian Gray (University of Edinburgh) and content expert Michael Marber (The Rayne Institute, St. Thomas' Hospital, King’s College London) about how Gray and colleagues used OPT to image the heart and capture 3-dimensional measurement of infarct volume. How does OPT stack up against standard histology and MRI? What exactly is giving rise to the autofluorescence signal when using OPT? Is there a future for OPT as a method of measuring infarct volume to transcend biological variations and the limitations of measuring individual sections of infarcted tissue? Listen to find out.

Xiaofeng Zhao, Junxi Wu, Calum D. Gray, Kieran McGregor, Adriano G Rossi, Harris Morrison, Maurits A Jansen, Gillian A Gray Optical projection tomography permits efficient assessment of infarct volume in the murine heart post-myocardial infarction Am J Physiol Heart Circ Physiol, published online June 12, 2015, DOI: 10.1152/ajpheart.00233.2015.


Exercise and Chemoreflex Control of Renal Blood Flow in Chronic Heart Failure

It is well known that reduced kidney function in chronic heart failure (CHF) patients leads to morbidity and mortality in a significant proportion of this clinical population. So how does exercise training fit into the picture? In this podcast, Deputy Editor Merry Lindsey (University of Mississippi Medical Center) interviews lead author Noah Marcus (Des Moines University) and content expert Timothy Musch (Kansas State University) about the innovative work by Marcus and colleagues utilizing a unique rabbit exercise training experimental model of poor renal function in CHF with reduced renal perfusion. We tackle a number of intriguing questions in this author interview! Does enhanced carotid body chemoreceptor activity mediate tonic and/or hypoxia-induced reductions in renal blood flow in heart failure? Can exercise training be used as a non-pharmacological treatment to improve renal blood flow in heart failure patients? Do rabbits really run on a treadmill? Listen to find out.

Noah J. Marcus, Carolin Pügge, Jai Mediratta, Alicia M. Schiller, Rodrigo Del Rio, Irving H. Zucker, Harold D. Schultz Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure Am J Physiol Heart Circ Physiol, published July 15, 2015, DOI: 10.1152/ajpheart.00268.2015.