Age-related Changes in Central Blood Pressures

What happens when you combine NSAID type pain medication and aging-induced arterial stiffening? Can cyclooxygenase inhibitors cause hemodynamic problems in older adults? Editor-in-chief Bill Stanley interviews lead author Jill Barnes (Mayo Clinic) and expert Judy Delp (University of Florida) about the new human study by Barnes and colleagues which looked at the central blood pressure response to the COX inhibitor indomethacin in both old and young healthy adults.

Jill Nicole Barnes, Darren P. Casey, Caesy N. Hines, Wayne T. Nicholson, and Michael J. Joyner Cyclooxygenase Inhibition Augments Central Blood Pressure and Aortic Wave Reflection in Aging Humans Am J Physiol Heart Circ Physiol, published online April 13, 2012, doi: 10.1152/ajpheart.00032.2012.