Exercise Training Increases GCH1 and Couples eNOS in Heart Failure

What is the mechanisms for the beneficial effects of exercise on coronary artery function in heart failure? Associate Editor Nancy Kanagy (University of New Mexico School of Medicine) interviews lead author Luciana Venturini Rossoni (University of Sao Paulo Biomedical Sciences Institute) and content expert Shane Phillips (University of Illinois-Chicago) about the fascinating new work by Couto et al in this engaging podcast. What mechanisms mediate the beneficial effects of aerobic exercise after heart failure? What role does tetrahydrobiopterin play in restoring coronary artery dilatory function? Listen and find out.

 

Gisele K. Couto, Suliana M. Paula, Igor L. Gomes-Santos, Carlos Eduardo Negrão, and Luciana V. Rossoni Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats Am J Physiol Heart Circ Physiol, published April 9, 2018. DOI: 10.1152/ajpheart.00624.2017