Renin-Angiotensin System Signaling in Aged and Age-Exercised Rats

Does aging influence myocardial angiotensin II levels in the heart? Listen as Editor in Chief Irving H. Zucker (University of Nebraska Medical Center) interviews lead author Dong Sun (New York Medical College) and content expert Zsolt Bagi (Augusta University) about the recent study by Froogh et al, which compared three experimental groups (young sedentary, aged sedentary, and aged exercising rats) to determine why there is a mismatch between angiotensin II and angiotensin 1 – 7 in the aged heart. Does perivascular chymase and angiotensin production specifically target blood vessels? What do the authors speculate is the mechanisms by which exercise can alter ACE and ACE 2, including chymase? Find out this and more. Listen now.

 

Ghezal Froogh, John T Pinto, Yicong Le, Sharath Kandhi, Yeabsra Aleligne, An Huang, Dong Sun Chymase-dependent production of angiotensin II: an old enzyme in old hearts Am J Physiol Heart Circ Physiol, published online November 4, 2016. DOI: 10.1152/ajpheart.00534.2016