TLR9 in Post-Infarct Cardiac Rupture

Is myocardial rupture in acute myocardial infarction preventable? Perhaps, according to new research by Omiya et al into the mechanisms underlying myocardial rupture in a toll-like receptor 9 knockout mouse model compared to a permanent coronary ligation model. In this podcast, Associate Editor Junichi Sadoshima (Rutgers New Jersey Medical School) interviews lead author Kinya Otsu (King's College London British Heart Foundation Centre of Excellence) and content expert Richard Kitsis (Albert Einstein College of Medicine) about the work by Otsu and colleagues exploring why toll-like receptor 9 shows cardioprotective effects on myocardial rupture but does not play a role in inflammation. Why are myocardial fibroblasts affected but inflammatory cells are not affected by TLR-9 knockout, and what exactly is the role of myofibroblasts in preventing cardiac rupture? What are the clinical implications for acute MI patients going forward? Listen and find out.

 

Shigemiki Omiya, Yosuke Omori, Manabu Taneike, Andrea Protti, Osamu Yamaguchi, Shizuo Akira, Ajay M. Shah, Kazuhiko Nishida, Kinya Otsu Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation Am J Physiol Heart Circ Physiol, published online December 1, 2016. DOI: 10.1152/ajpheart.00481.2016