TNF and Cardiac Stem Cell Differentiation

Why is the post- myocardial infarction micro environment of the heart so hostile for cardiac stem cells? In this podcast, Deputy Editor Merry Lindsey (University of Mississippi Medical Center) interviews lead author Sumanth Prabhu (University of Alabama at Birmingham) and content expert Richard Gumina (Vanderbilt University) about the work by Hamid et al, which determined that tumor necrosis factor (TNF) signaling inhibits endogenous cardiac stem cell repair and blunts stem cell treatment efficacy in human heart failure. What relationship did Prabhu and co-authors uncover between TNF-alpha and adrenergic activation? How did the authors manage the biological variability of primary stem cell isolates in their technically nuanced study? Finally, if “timing is everything” holds true, does this study provide a clinical translation roadmap for timing TNF receptor blockade post-MI? Listen to learn more.

Tariq Hamid, Yuanyuan Xu, Mohamed Ameen Ismahil, Qianhong Li, Steven P. Jones, Aruni Bhatnagar, Roberto Bolli, Sumanth D. Prabhu TNF receptor signaling inhibits cardiomyogenic differentiation of cardiac stem cells and promotes a neuroadrenergic-like fate Am J Physiol Heart Circ Physiol, published November 1, 2016. DOI: 10.1152/ajpheart.00904.2015