Archive for September 2020

Endothelial ERBB4 and Cardiac Remodeling

Does neuregulin-1 autocrine signaling by endothelial cells regulate left ventricular remodeling? Listen as Deputy Editor Merry Lindsey (University of Nebraska Medical Center) interviews lead authors Gilles De Keulenaer and Vincent Segers (both at University of Antwerp), along with expert Ganesh Halade (University of South Florida), about the novel work by Dugaucquier et al. The authors investigated responses to pressure overload using transverse aortic constriction, angiontensin II infusion, and myocardial infarction, in an endothelial cell-specific ERBB4 knockout mouse model. Surprising results serve to highlight the spatial and temporal heterogeneity of left ventricular autocrine and paracrine responses to cardiac injury. What’s more, these results lead the authors to believe that paracrine and autocrine signaling are integrally connected and equally influential on cardiac remodeling. “By performing this study, we now look at autocrine signaling in the myocardium in a completely different fashion,” explained De Keulenaer. Why? Listen now.


Lindsey Dugaucquier, Eline Feyen, Ligia Mateiu, Tine Anne Marie Bruyns, Gilles W. De Keulenaer, Vincent F. M. Segers The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling Am J Physiol Heart Circ Physiol, published August 4, 2020. DOI:

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Behind the Bench Episode 6 with Aurore Lyon

Everyone has a story, and no one is ordinary. That’s our theme for this episode of Behind the Bench from AJP-Heart and Circ. Hosts Lisandra de Castro Bras (East Carolina University) and Jonathan Kirk (Loyola University Chicago) talk with Aurore Lyon (Maastricht University), the first author of “Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model,” published in August 2020. Aurore pursued a master’s degree, followed by a PhD, at Oxford University. She is now completing a post-doctoral fellowship in the Department of Biomedical Engineering within the Cardiovascular Research Institute Maastricht at Maastricht University. Aurore’s story is about finding a passion in an unexpected field while pursuing research in a completely different area. From engineering to cardiovascular research, Aurore brings a refreshing perspective to navigating career and life across countries and cultures. Ready to change directions in your own career? Listen for inspiration.


Aurore Lyon, Lauren J. Dupuis, Theo Arts, Harry J. G. M. Crijns, Frits W. Prinzen, Tammo Delhaas, Jordi Heijman, Joost Lumens Differentiating the effects of β-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model Am J Physiol Heart Circ Physiol, published August 19, 2020. DOI:

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Vascular Response to Prolonged Sitting in Hypercapnia

What are the potential detrimental interactions between prolonged sitting and mild hypercapnia on autonomic system activity, vascular function, and microvascular oxygenation? In this episode, Editor-in-Chief Irv Zucker (University of Nebraska Medical Center) interviews lead author Song-Young Park (University of Nebraska at Omaha) and expert Camilla Wenceslau (University of Toledo) about the latest study by Headid et al., which found that prolonged sitting attenuated systemic and peripheral vascular endothelial function, as well as microvascular function in healthy adults. Park and co-authors also found that prolonged sitting coupled with mild hypercapnic conditions that mimic everyday environments in workplaces, office buildings, and school classrooms resulted in exacerbated peripheral vascular and microvascular dysfunction. Listen as we discuss how prolonged sitting may aggravate disease conditions such as sleep apnea, COPD, and obesity. What are the potential implications of this research for students spending long hours sitting indoors with restricted movement due to COVID-19 pandemic restrictions? Listen to find out.


Ronald J. Headid 3rd, Elizabeth J. Pekas, TeSean K. Wooden, Won-Mok Son, Gwenael Layec, John Shin, Song-Young Park Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults Am J Physiol Heart Circ Physiol, published August 4, 2020. DOI:

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[U-13C]-glucose and In Vivo Heart Metabolism

What is the “metabolic fate” of glucose in mice with pressure-overload or volume-overload induced cardiac hypertrophy? Listen as Associate Editor Fabio Recchia (Temple University and Scuola Superiore Sant'Anna) interviews lead author, and fellow Associate Editor, Ajay Shah (King’s College London) along with experts Christoph Maack and Edoardo Bertero (both at University Clinic Würzburg) about the new study by Schnelle et al. “Metabolism is integrally linked to structural and functional changes that occur in the remodeling heart.” By implementing a method of heavy carbon labeling in vivo, and utilizing nuclear magnetic resonance spectroscopy, Schnelle et al. found notable differences in the pressure-overload mouse model of transverse aortic constriction (TAC) but not in the volume-overload TAC model. What is the significance of an increase in flux in the tricarboxylic acid cycle (TCA) during pressure-overload? How did the authors interpret the evidence of increased glutamine and aspartate, neither of which are TCA metabolites? Listen to find out.


Moritz Schnelle, Mei Chong, Anna Zoccarato, Manar Elkenani, Greta Jane Sawyer, Gerd Hasenfuss, Christian Ludwig, Ajay M. Shah In vivo [U-13C]glucose labeling to assess heart metabolism in murine models of pressure and volume overload Am J Physiol Heart Circ Physiol, published August 4, 2020. DOI:

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