Endothelial ERBB4 and Cardiac Remodeling

Does neuregulin-1 autocrine signaling by endothelial cells regulate left ventricular remodeling? Listen as Deputy Editor Merry Lindsey (University of Nebraska Medical Center) interviews lead authors Gilles De Keulenaer and Vincent Segers (both at University of Antwerp), along with expert Ganesh Halade (University of South Florida), about the novel work by Dugaucquier et al. The authors investigated responses to pressure overload using transverse aortic constriction, angiontensin II infusion, and myocardial infarction, in an endothelial cell-specific ERBB4 knockout mouse model. Surprising results serve to highlight the spatial and temporal heterogeneity of left ventricular autocrine and paracrine responses to cardiac injury. What’s more, these results lead the authors to believe that paracrine and autocrine signaling are integrally connected and equally influential on cardiac remodeling. “By performing this study, we now look at autocrine signaling in the myocardium in a completely different fashion,” explained De Keulenaer. Why? Listen now.


Lindsey Dugaucquier, Eline Feyen, Ligia Mateiu, Tine Anne Marie Bruyns, Gilles W. De Keulenaer, Vincent F. M. Segers The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling Am J Physiol Heart Circ Physiol, published August 4, 2020. DOI: doi.org/10.1152/ajpheart.00176.2020

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