What exactly is cardiac denervation, and can it have an anti-arrhythmic effect in the setting of chronic myocardial infarction? Listen as Associate Editor Mario Delmar (New York University) interviews lead author Marmar Vaseghi (UCLA Cardiac Arrhythmia Center) and Consulting Editor and content expert Crystal Ripplinger (University of California, Davis) about this translational study by Vaseghi and colleagues, which used a porcine model to determine if bilateral cardiac sympathetic denervation reduced ventricular tachy-arrhythmia inducibility in both normal and infarcted hearts. What are the possible short-term and long-term changes in the regulation of the inotropic response resulting from the denervation? What are the cellular mechanisms responsible for changes in action potential durations? Listen to find out.
Tadanobu Irie, Kentaro Yamakawa, David Hamon, Keijiro Nakamura, Kalyanam Shivkumar, Marmar Vaseghi Cardiac sympathetic innervation via middle cervical and stellate ganglia and antiarrhythmic mechanism of bilateral stellectomy Am J Physiol Heart Circ Physiol, published March 1, 2017. DOI: 10.1152/ajpheart.00644.2016