Deformation Causes Vascular Alignment During Angiogenesis

What does “changing the boundary conditions” mean? In our latest author interview, Deputy Editor Dr. Merry Lindsey asks lead author Dr. Jeffrey Weiss (University of Utah) this very question about his innovative new work exploring the relationship between tissue mechanics and angiogenesis. Expert Hai-Chao Han (University of Texas at San Antonio) lends his insight into the importance of studying the mechanics of blood vessel formation. Will the work by Underwood et al, which elegantly blends computational and biological approaches, someday lead to new experimental applications, such as pre-aligned microvasculatures for engineered tissue constructs? Listen and learn.

Clayton J. Underwood, Lowell T. Edgar, James B. Hoying, Jeffrey A. Weiss Cell-generated traction forces and the resulting matrix deformation modulate microvascular alignment and growth during angiogenesis Am J Physiol Heart Circ Physiol, published July 15, 2014. DOI: 10.1152/ajpheart.00995.2013.

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