AJP-Heart and Circulatory Physiology Podcasts

Endothelial Control of Blood Pressure

January 25, 2018

Do changes in endothelial function in a high-fat, high-sugar diet model of metabolic syndrome mitigate the effects of elevated sympathetic nervous system activity to increase blood pressure? Listen as Associate Editor Debra Diz (Wake Forest University School of Medicine) interviews first author Sylvain Battault (Avignon University, France) and content expert Julie Y.H. Chan (Chung Gung Memorial Hospital, Taiwan) about the intriguing new work by Battault and co-authors which has potential clinical implications for obesity with, and without, hypertension. Did the authors find that an increase in autonomic sympathetic outflow translates to high blood pressure in their model of metabolic syndrome? Does this study suggest that the endothelium modulates adrenergic-dependent vasoconstriction as a last-chance defense mechanism against metabolic syndrome -associated hypertension? Listen and find out.


Sylvain Battault, Cindy Meziat, Alessandro R Nascimento, Laura Braud, Sandrine Gayrard, Christian Legros, Frederic De Nardi, Jocelyne Drai, Olivier Cazorla, Jérôme Thireau, Gregory Meyer, and Cyril Reboul Vascular endothelial function masks increased sympathetic vasopressor activity in rats with metabolic syndrome Am J Physiol Heart Circ Physiol, published November 10, 2017. DOI: doi/10.1152/ajpheart.00217.2017

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