Are circulating exosomes in serum derived from pediatric patients with dilated cardiomyopathy modulating the phenotype of cardiomyocytes and causing a pathological response in cells? Yes, according to a novel and technically-challenging in vitro study by Jiang et al. Listen as Guest Editor Sumanth Prabhu (University of Alabama at Birmingham) interviews lead author Carmen (Kika) Sucharov (University of Colorado Denver) and David D. Gutterman (Medical College of Wisconsin), content expert and Consulting Editor. Exosomes are small vesicles present in cells and released into the circulation carrying both coding and noncoding RNAs, as well as proteins and lipids. The study by Sucharov and co-authors seeks to further elucidate the unique features of the pathophysiology of heart failure in children. Does this study also provide a roadmap for future research into the “culprit component” of exosomes responsible for the phenotypic change shown in cardiomyocytes by the Sucharov lab? Listen and learn more.
Xuan Jiang, Juliana Sucharov, Brian L. Stauffer, Shelley D. Miyamoto, Carmen C. Sucharov Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes Am J Physiol Heart Circ Physiol, published April 1, 2017. DOI: 10.1152/ajpheart.00673.2016