G6PD Deficiency and Cardiovascular Disease

What can we learn from the most common enzyme deficiency in the world? Quite a lot, actually. G6PD deficiency has cascading effects on NADPH, reactive oxygen species production, and anti-oxidant reserves, all outlined in a comprehensive new Review article by Hecker et al. Associate Editor Ajay Shah interviews first author Peter Hecker (Washington University in St. Louis) as well as leading expert, and Associate Editor, Ronglih Liao (Brigham and Women's Hospital and Harvard Medical School) about compartmentalization, potential drug therapies, and where the study of G6PD deficiency will lead to next.

Peter A. Hecker, Jane A. Leopold, Sachin A. Gupte, Fabio A. Recchia, and William C. Stanley Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease Am J Physiol Heart Circ Physiol, published online December 15, 2012, doi: 10.1152/ajpheart.00721.2012.

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