With increased focus on rigor and reproducibility in basic science, is now the best time to set the record straight on measuring cardiac physiology in mice? Yes, according to five experts who collaborated to write new comprehensive Guidelines in Cardiovascular Research on this vitally important topic. Listen as Consulting Editor David A. Kass (Johns Hopkins University School of Medicine) interviews co-authors Merry Lindsey (University of Mississippi Medical Center), Zamaneh Kassiri (University of Alberta, Canada), Jitka Virag (East Carolina University), Lisandra E. de Castro Bras (East Carolina University), and Marielle Scherrer-Crosbie (Hospital of the University of Pennsylvania). The authors discuss the strengths and limitations of various imaging modalities used to evaluate cardiac physiology, as well as their extensive literature analysis which led to the development of a checklist for authors and reviewers of minimum cardiac physiology information to be included in manuscript methods. In addition to echocardiography, echo Doppler, and MRI, what would these experts like to see developed for a “toolbox of the future”? Listen and find out.
Merry L. Lindsey, Zamaneh Kassiri, Jitka Amira Ismail Virag, Lisandra E. de Castro Bras, and Marielle Scherrer-Crosbie Guidelines for Measuring Cardiac Physiology in Mice Am J Physiol Heart Circ Physiol, published January 5, 2018. DOI: doi/10.1152/ajpheart.00339.2017