MMP-2 is Localized to the Mitochondria-Associated Membrane of the Heart

Is matrix metalloproteinase MMP-2 in the mitochondria of cardiomyocytes, near the mitochondria, or both? “In order to figure out what this protease is doing, you need to know precisely where it is,” says Richard Schulz (University of Alberta), lead author of the recent study by Hughes et al. In this podcast, Associate Editor Merry Lindsey (University of Mississippi Medical Center) interviews Shulz and expert Francisco Villarreal (University of California-San Diego) about this fascinating new work bringing fresh insights into the pattern of MMP subcellular distribution. Find out what’s in the MMP inhibitor clinical trial pipeline, and get a bird’s eye view of how the MMP biology field is evolving. Listen now.

Bryan G. Hughes, Xiaohu Fan, Woo Jung Cho, Richard Schulz. MMP-2 is localized to the mitochondria-associated membrane of the heart Am J Physiol Heart Circ Physiol, published December 27, 2013, doi: 10.1152/ajpheart.00909.2013.

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