Episodes

Tuesday Jan 29, 2013
Sex Differences and Vascular Reactivity to Mental Stress
Tuesday Jan 29, 2013
Tuesday Jan 29, 2013
Do men and women handle mental stress differently? What role do sex differences play in the transduction of muscle sympathetic nerve activity (MSNA) into vascular tone during stress? Associate Editor Irving Zucker explores the recent work by Yang et al in our new podcast interview with lead author Jason Carter (Michigan Technological University) and expert Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) in a stimulating conversation germane to the wave of research on sex differences in cardiovascular science. Listen now.
Huan Yang, Thomas Drummer, and Jason R. Carter Sex differences in sympathetic neural and limb vascular reactivity to mental stress in humans Am J Physiol Heart Circ Physiol, published online November 30, 2012, doi: 10.1152/ajpheart.00688.2012.

Friday Jan 11, 2013
Endothelin-1 and Exercise
Friday Jan 11, 2013
Friday Jan 11, 2013
How can we tame the sleeping giant of excess skeletal muscle blood flow during exercise? In our latest podcast we expand our understanding of the role endothelin-1 plays in regulating skeletal muscle blood flow during whole body, as well as targeted, exercise in healthy patients. Consulting Editor David Gutterman leads this interesting conversation with author Walter Wray (University of Utah) and expert Kevin Dellsperger (University of Missouri-Columbia) about the recent work by Barrett-O’Keefe et al. What are the possibilities for targeting the endothelin-1 pathway in disease states? Listen now.
Zachary Barrett-O'Keefe, Stephen J. Ives, Joel Douglas Trinity, Richard Garrett Morgan, Matthew Jordan Rossman, Anthony J. Donato, Sean Runnels, David E. Morgan, Benjamin S. Gmelch, Amber D. Bledsoe, Russell S. Richardson, and D. Walter Wray Taming the "Sleeping Giant": The Role of Endothelin-1 in the Regulation of Skeletal Muscle Blood Flow and Arterial Blood Pressure during Exercise Am J Physiol Heart Circ Physiol, published online October 26, 2012, doi:10.1152/ajpheart.00603.2012.

Monday Dec 17, 2012
MMPs: Milestones, Myths, and (Mis)Perceptions
Monday Dec 17, 2012
Monday Dec 17, 2012
So you thought that the role of matrix metalloproteinases (MMPs) in myocardial remodeling had been all worked out? Well, it's not so simple. The latest Review article by Iyer et al debunks myths and demystifies perceptions surrounding MMPs and their role in regulating the extracellular matrix and cardiac structure. In our new podcast, Editor in Chief William Stanley interviews lead author Merry Lindsey (University of Texas Health Science Center San Antonio) and expert Loren Wold (The Research Institute at Nationwide Children's Hospital) about the work by Lindsey and others in the MMP/TIMP field. Listen now to discover more.
Rugmani Padmanabhan Iyer, Nicolle L. Patterson, Gregg B. Fields, and Merry L. Lindsey The history of matrix metalloproteinases: milestones, myths, and misperceptions Am J Physiol Heart Circ Physiol, published online August 17, 2012, doi: 10.1152/ajpheart.00577.2012.

Tuesday Dec 11, 2012
Right Ventricular Arrhythmogenic Remodeling in Heart Failure
Tuesday Dec 11, 2012
Tuesday Dec 11, 2012
Can translational research using donated human hearts uncover the mechanism behind cardiac sudden death in heart failure patients? In our latest podcast, Editor in Chief William Stanley interviews renowned researcher Igor Efimov (Washington University) and global expert Kenneth Laurita (Case Western Reserve University) about the latest work by Lou et al. demonstrating enhanced dispersion of repolarization in right ventricles obtained from heart failure patients.
Qing Lou, Deborah L Janks, Katherine Holzem, Di Lang, Birce Onal, Christina M Ambrosi, Vadim V Fedorov, I-Wen Wang, and Igor R. Efimov Right Ventricular Arrhythmogenesis in Failing Human Heart: The Role of Conduction and Repolarization Remodeling Am J Physiol Heart Circ Physiol, published online October 5, 2012, doi: 10.1152/ajpheart.00457.2012.

Monday Nov 26, 2012
Sildenafil and Exercise Muscle Oxygenation in Chronic Heart Failure
Monday Nov 26, 2012
Monday Nov 26, 2012
What is arguably the most famous drug side effect of all time? Back in 1992 sildenafil, a PDE5 inhibitor, was ineffective for treatment of ischemic heart disease, but went on to become a blockbuster drug for erectile dysfunction. In our latest podcast Senior Associate Editor David A. Kass interviews lead author Alberto Neder and expert David Poole about the recent work by Sperandio et al, which demonstrates how sildenafil can improve the cardiovascular response to exercise in heart failure patients. Will current clinical trials show that sildenafil benefits cardiac remodeling and vascular dysfunction in heart failure?
Priscila A Sperandio, Mayron F Oliveira, Miguel K Rodrigues, Danilo C Berton, Erika Treptow, Luiz E Nery, Dirceu R Almeida, and J. Alberto Neder Sildenafil Improves Microvascular O2 Delivery-to-Utilization Matching and Accelerates Exercise O2 Uptake Kinetics in Chronic Heart Failure Am J Physiol Heart Circ Physiol, published online September 28, 2012, doi:10.1152/ajpheart.00435.2012.

Thursday Oct 18, 2012
Oxidative Stress and Hemodynamics in Heart Failure
Thursday Oct 18, 2012
Thursday Oct 18, 2012
Why are heart failure patients exercise intolerant? Is it due to oxidative stress? In our latest podcast, Editor in Chief William Stanley talks with first author Melissa Witman (University of Utah) about her study that assessed the impact of an “antioxidant cocktail” on central and peripheral hemodynamics during exercise in heart failure patients. Carlos Negrao (University of Sao Paulo) lends his expert opinion in this lively conversation. Listen and learn.
Melissa A. H. Witman, John McDaniel, Anette S. Fjeldstad, Stephen J. Ives, Jia Zhao, Jose N. Nativi, Josef Stehlik, D. Walter Wray, and Russell S. Richardson A Differing Role of Oxidative Stress in the Regulation of Central and Peripheral Hemodynamics during Exercise in Heart Failure Am J Physiol Heart Circ Physiol, published online September 7, 2012, doi: 10.1152/ajpheart.00568.2012.

Thursday Oct 04, 2012
Gene and Cytokine Therapy for Heart Failure
Thursday Oct 04, 2012
Thursday Oct 04, 2012
The Editors of AJP-Heart and Circulatory Physiology are excited to present our first ever podcast in both English and Japanese! Associate Editor Masafumi Kitakaze interviews lead author Toshio Nagai (Chiba University) and Editorial Board member Takashi Matsui (University of Hawaii) about the new Review article by Nagai and Komuro on cutting-edge research involving gene and cytokine therapies for heart failure. We cover everything from the molecular level to clinical trials, in two languages!
Toshio Nagai and Issei Komuro Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function Am J Physiol Heart Circ Physiol, published online July 9, 2012, doi: 10.1152/ajpheart.00130.2012.

Thursday Oct 04, 2012
JAPANESE VERSION: Gene and Cytokine Therapy for Heart Failure
Thursday Oct 04, 2012
Thursday Oct 04, 2012
Listen to our Japanese language podcast on the Review article by Toshio Nagai and Issei Komuro.
Toshio Nagai and Issei Komuro Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function Am J Physiol Heart Circ Physiol, published online July 9, 2012, doi: 10.1152/ajpheart.00130.2012.

Wednesday Sep 19, 2012
Vascular Effects of Maternal Alcohol Consumption
Wednesday Sep 19, 2012
Wednesday Sep 19, 2012
What are the effects of drinking alcohol during pregnancy on the mother’s cardiovascular system? The simple answer is that we are still trying to find out. Research has long focused on fetal alcohol spectrum disorders, but little research has been done on the effects of both acute and chronic alcohol consumption on the maternal circulation that might contribute to pregnancy disorders such as preeclampsia and gestational diabetes and to long term effects on the offspring. For a review of this emerging field, listen to our latest podcast as Associate Editor Nancy Kanagy interviews lead author Jayanth Ramadoss (University of Texas Medical Branch) and expert William Mayhan (LSU Health Sciences Center) about the recent review by Ramadoss and Magness.
Jayanth Ramadoss and Ronald R. Magness Vascular effects of maternal alcohol consumption Am J Physiol Heart Circ Physiol, published online June 22, 2012, doi: 10.1152/ajpheart.00127.2012.

Friday Sep 07, 2012
Microcalcifications in Vulnerable Plaque Rupture
Friday Sep 07, 2012
Friday Sep 07, 2012
What are the actual mechanisms of plaque rupture? How can we integrate the new findings by Maldonado et al in the context of a threshold for rupture of vulnerable plaque? In this podcast, Associate Editor Ivor Benjamin interviews senior author Sheldon Weinbaum (The City College of the City University of New York) and leading expert Linda Demer (UCLA School of Medicine) about the work by Weinbaum and colleagues on coronary artery calcification and the use of microCT to identify microcalcifications. Are microcalcifications the "smoking gun" for triggering inflammation-induced atherosclerosis? Listen now.
Natalia Maldonado, Adreanne Kelly-Arnold, Yuliya Vengrenyuk, Damien Laudier, John T Fallon, Renu Virmani, Luis Cardoso, and Sheldon Weinbaum A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability - potential implications for plaque rupture Am J Physiol Heart Circ Physiol, published online July 9, 2012, doi: 10.1152/ajpheart.00036.2012.