AJP-Heart and Circulatory Physiology Podcast

Right Ventricular Arrhythmogenic Remodeling in Heart Failure

Can translational research using donated human hearts uncover the mechanism behind cardiac sudden death in heart failure patients? In our latest podcast, Editor in Chief William Stanley interviews renowned researcher Igor Efimov (Washington University) and global expert Kenneth Laurita (Case Western Reserve University) about the latest work by Lou et al. demonstrating enhanced dispersion of repolarization in right ventricles obtained from heart failure patients.

Qing Lou, Deborah L Janks, Katherine Holzem, Di Lang, Birce Onal, Christina M Ambrosi, Vadim V Fedorov, I-Wen Wang, and Igor R. Efimov Right Ventricular Arrhythmogenesis in Failing Human Heart: The Role of Conduction and Repolarization Remodeling Am J Physiol Heart Circ Physiol, published online October 5, 2012, doi: 10.1152/ajpheart.00457.2012.

Sildenafil and Exercise Muscle Oxygenation in Chronic Heart Failure

What is arguably the most famous drug side effect of all time? Back in 1992 sildenafil, a PDE5 inhibitor, was ineffective for treatment of ischemic heart disease, but went on to become a blockbuster drug for erectile dysfunction. In our latest podcast Senior Associate Editor David A. Kass interviews lead author Alberto Neder and expert David Poole about the recent work by Sperandio et al, which demonstrates how sildenafil can improve the cardiovascular response to exercise in heart failure patients. Will current clinical trials show that sildenafil benefits cardiac remodeling and vascular dysfunction in heart failure?

Priscila A Sperandio, Mayron F Oliveira, Miguel K Rodrigues, Danilo C Berton, Erika Treptow, Luiz E Nery, Dirceu R Almeida, and J. Alberto Neder Sildenafil Improves Microvascular O2 Delivery-to-Utilization Matching and Accelerates Exercise O2 Uptake Kinetics in Chronic Heart Failure Am J Physiol Heart Circ Physiol, published online September 28, 2012, doi:10.1152/ajpheart.00435.2012.

Oxidative Stress and Hemodynamics in Heart Failure

Why are heart failure patients exercise intolerant? Is it due to oxidative stress? In our latest podcast, Editor in Chief William Stanley talks with first author Melissa Witman (University of Utah) about her study that assessed the impact of an “antioxidant cocktail” on central and peripheral hemodynamics during exercise in heart failure patients. Carlos Negrao (University of Sao Paulo) lends his expert opinion in this lively conversation. Listen and learn.

Melissa A. H. Witman, John McDaniel, Anette S. Fjeldstad, Stephen J. Ives, Jia Zhao, Jose N. Nativi, Josef Stehlik, D. Walter Wray, and Russell S. Richardson A Differing Role of Oxidative Stress in the Regulation of Central and Peripheral Hemodynamics during Exercise in Heart Failure Am J Physiol Heart Circ Physiol, published online September 7, 2012, doi: 10.1152/ajpheart.00568.2012.

Gene and Cytokine Therapy for Heart Failure

The Editors of AJP-Heart and Circulatory Physiology are excited to present our first ever podcast in both English and Japanese! Associate Editor Masafumi Kitakaze interviews lead author Toshio Nagai (Chiba University) and Editorial Board member Takashi Matsui (University of Hawaii) about the new Review article by Nagai and Komuro on cutting-edge research involving gene and cytokine therapies for heart failure. We cover everything from the molecular level to clinical trials, in two languages!

Toshio Nagai and Issei Komuro Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function Am J Physiol Heart Circ Physiol, published online July 9, 2012, doi: 10.1152/ajpheart.00130.2012.

JAPANESE VERSION: Gene and Cytokine Therapy for Heart Failure

Listen to our Japanese language podcast on the Review article by Toshio Nagai and Issei Komuro.

Toshio Nagai and Issei Komuro Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function Am J Physiol Heart Circ Physiol, published online July 9, 2012, doi: 10.1152/ajpheart.00130.2012.

Vascular Effects of Maternal Alcohol Consumption

What are the effects of drinking alcohol during pregnancy on the mother’s cardiovascular system? The simple answer is that we are still trying to find out. Research has long focused on fetal alcohol spectrum disorders, but little research has been done on the effects of both acute and chronic alcohol consumption on the maternal circulation that might contribute to pregnancy disorders such as preeclampsia and gestational diabetes and to long term effects on the offspring. For a review of this emerging field, listen to our latest podcast as Associate Editor Nancy Kanagy interviews lead author Jayanth Ramadoss (University of Texas Medical Branch) and expert William Mayhan (LSU Health Sciences Center) about the recent review by Ramadoss and Magness.

Jayanth Ramadoss and Ronald R. Magness Vascular effects of maternal alcohol consumption Am J Physiol Heart Circ Physiol, published online June 22, 2012, doi: 10.1152/ajpheart.00127.2012.

Microcalcifications in Vulnerable Plaque Rupture

What are the actual mechanisms of plaque rupture? How can we integrate the new findings by Maldonado et al in the context of a threshold for rupture of vulnerable plaque? In this podcast, Associate Editor Ivor Benjamin interviews senior author Sheldon Weinbaum (The City College of the City University of New York) and leading expert Linda Demer (UCLA School of Medicine) about the work by Weinbaum and colleagues on coronary artery calcification and the use of microCT to identify microcalcifications. Are microcalcifications the "smoking gun" for triggering inflammation-induced atherosclerosis? Listen now.

Natalia Maldonado, Adreanne Kelly-Arnold, Yuliya Vengrenyuk, Damien Laudier, John T Fallon, Renu Virmani, Luis Cardoso, and Sheldon Weinbaum A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability - potential implications for plaque rupture Am J Physiol Heart Circ Physiol, published online July 9, 2012, doi: 10.1152/ajpheart.00036.2012.

Ischemic Preconditioning and Exercise-Induced Endothelium-Dependent Function

What do elite athletes and remote preconditioning have in common? With the 2012 London Olympic Games underway, our Consulting Editor David Gutterman interviews lead author Dick Thijssen (Liverpool John Moores University) and expert Michael Widlansky (Medical College of Wisconsin) about the work by Bailey et al, which investigates how a preconditioning ischemic stimulus applied to the legs could provide protection against endothelial dysfunction in the arms after intense exercise. Could the observation that improved performance times on a 5K run after remote preconditioning lead to new training techniques to improve performance for Olympic athletes? Is this tantamount to doping? Listen in and find out.

Tom G. Bailey, Gurpreet K. Birk, N. Timothy Cable, Greg Atkinson, Daniel J. Green, Helen Jones, and Dick H.J. Thijssen Remote Ischemic Preconditoning Prevents Reduction in Brachial Artery Flow Mediated Dilation after Strenuous Exercise Am J Physiol Heart Circ Physiol, published online June 22, 2012, doi: 10.1152/ajpheart.00272.2012.

Cell-Based Therapy for Prevention and Reversal of Myocardial Remodeling

Where are the prospects for cell-based therapies for myocardial infarction and heart failure? Listen as Editor in Chief William C. Stanley discusses stem cell therapies for heart disease and the new Review article by Karantalis et al with senior author Joshua Hare (University of Miami) and leading expert Jianyi (Jay) Zhang (University of Minnesota). This paper thoroughly examines cell-based therapies for treatment of acute myocardial infarction and chronic ischemic cardiomyopathy. What are the prospects for moving cell therapies out of the lab and into routine clinical practice?

Vasileios Karantalis, Wayne Balkan, Ivonne Hernandez Schulman, Konstantinos Hatzistergos, and Joshua M. Hare Cell-Based Therapy for Prevention and Reversal of Myocardial Remodeling Am J Physiol Heart Circ Physiol, published online May 25, 2012, doi: 10.1152/ajpheart.00221.2012.

Physiological Aspects of Cardiac Tissue Engineering

How do you grow cardiac muscle in a dish? Listen as myocardial tissue engineering pioneer Thomas Eschenhagen (University Medical Center Hamburg Eppendorf) talks with Associate Editor Leon de Windt and leading expert Pieter Doevendans (University of Utrecht Medical Centre) about the evolution of cardiac tissue engineering. From humble beginnings in chick embryonic cardiomyocytes to current state-of-the-art techniques with human tissue, we explore the development of engineered myocardium for drug screening and clinical applications.

Thomas Eschenhagen, Alexandra Eder, Ingra Vollert, and Arne Hansen Physiological Aspects of Cardiac Tissue Engineering Am J Physiol Heart Circ Physiol, published online May 11, 2012, doi: 10.1152/ajpheart.00007.2012.