Myocardial infarction is a global health problem, and accordingly, treatment and prevention are the focus of a significant number of basic cardiovascular research projects. Animal models of myocardial ischemia, with or without reperfusion, are commonly used to study myocardial infarction, but with little guidance on best practices. Enter our new Guidelines in Cardiovascular Research article on “Guidelines for Experimental Models of Myocardial Ischemia and Infarction,” the result of a year-long collaboration of 20 internationally-recognized experts. Listen as Editor in Chief Irving H. Zucker (University of Nebraska Medical Center) interviews authors Merry Lindsey (University of Mississippi Medical Center), Gerd Heusch (Universitatsklinikum Essen), Karyn Przyklenk (Wayne State University School of Medicine), Elizabeth G. Murphy (NIH, National Heart, Lung, and Blood Institute), and Steven P. Jones (University of Louisville) about this comprehensive work establishing guidelines for rigor and reproducibility when using ischemia models. Strengths and limitations of a wide-range of specific models are analyzed, and the authors provide a veritable checklist for animal usage, study design, and experimental procedures. The authors also list data output details, in particular for in vivo studies, in easy-to-read table format. Listen as we unpack this landmark Guidelines in Cardiovascular Research article in this engaging conversation with key leaders in the field.
Merry L. Lindsey, Roberto Bolli, John M. Canty, Xiao-Jun Du, Nikolaos G. Frangogiannis, Stefan Frantz, Robert G. Gourdie, Jeffrey W. Holmes, Steven P. Jones, Robert Kloner, David J. Lefer, Ronglih Liao, Elizabeth Murphy, Peipei Ping, Karin Przyklenk, Fabio A. Recchia, Lisa Schwartz Longacre, Crystal May Ripplinger, Jennifer E Van Eyk, and Gerd Heusch Guidelines for Experimental Models of Myocardial Ischemia and Infarction Am J Physiol Heart Circ Physiol, published January 12, 2018. DOI: doi/10.1152/ajpheart.00335.2017